An overview of modern medicine for the treatment of prostatitis and prostate adenoma

Male urological diseases, such as prostate adenoma and prostatitis, are characterized by significant effects on a man’s quality of life. Urinary incontinence, pain syndrome, decreased sexual activity, infertility and many other problems are reasons to contact a specialist. The variety of medications produced for prostate adenoma allows you to avoid surgical interventions, complications and other unpleasant changes in a man’s life.

Remedies for prostate adenoma

medicine for prostatitis

The appointment of drugs is carried out individually, depending on the nature of the course of the disease and is determined by a set of criteria:

  1. Prevalence of certain types of symptomatology:
    • irritating (frequent urination, urinary incontinence, nocturnal urge, strong desire to urinate, uncontrollable);
    • obstructive (difficulty urinating, weakening of jet pressure, dripping).
    • Presence / absence of complications.
    • Diagnostic data:
      • Ultrasound (size);
      • characteristics of urine flow, the presence of residual urine.
      • Presence / absence of comorbidities.
      • The presence of infectious complications.
      • The degree of damage to the bladder and kidneys.
      • Relevance of sexual activity for men.

Medications for prostate adenoma can have various routes of administration:

  • injection;
  • pill;
  • rectal suppositories;
  • instillation (introduction of material into the urethra);
  • microclister.

The point of use of drugs is a specific link in the pathogenesis of the disease, based on this, they are combined into groups.

Alpha blocker

pills for prostatitis

This group leads in the treatment of benign prostatic hyperplasia (BPH).

In the glands affected by tumors, urethra and bladder, the number of alpha-adrenoceptors increases, and the progression of the disease contributes to their excessive stimulation, resulting in spasm of the smooth muscles of the organs, which explains the occurrence. of irritating symptoms. The principle of operation of the drug is to bind the active substance to the α₁-adrenergic receptors of the genitourinary organs and block them.

Several subtypes of alpha-1-adrenergic receptors are known, located not only in the genitourinary organs, but also in the walls of major human arteries. If drugs from this group do not selectively bind to receptors, but bind to all subtypes of adrenergic receptors, then this will lead to some side effects from the heart and blood vessels. There are several alpha blockers that selectively bind to α₁-adrenergic receptors.

The drug for prostate adenoma, which contains tamsulosin, terazosin, doxazosin as active ingredients, is considered to be drug No. 1 among alpha blockers in the treatment of BPH.

These substances selectively and for a long time block adrenergic receptors.

Reasons for choosing an alpha blocker:

  • moderate and severe symptoms of the disease;
  • predominance of symptoms of severe irritation;
  • the volume of the enlarged organ is not more than 55 cm³ (the drug does not contribute to the reduction in size).

Advantage:

  • eliminate symptoms after 48 hours from the moment of application;
  • do not reduce the level of prostate -specific antigens in the blood (do not cover prostate cancer);
  • increase fat metabolism (reduce cholesterol);
  • increase the sensitivity of receptors to insulin (prevention of diabetes mellitus);

The obvious effect of use occurs after a few weeks from the start of administration and reaches a maximum after 3-6 months.

Side effects: orthostatic hypotension, tachycardia, dry mouth, nausea, abdominal pain, headache, weakness, impotence, reflux of sperm inverted into the bladder during ejaculation, visual disturbances, etc. Undesirable effects occur in about 15% of patients.

This drug causes a decrease in blood pressure, so the initial dose in the treatment of drugs from this group of prostatitis is minimal.

Form of drug release: tablets and capsules.

5-alpha reductase inhibitors

medicine for prostatitis

The development of BPH is based on age -related hormonal changes related to testosterone metabolism. In organ cells, testosterone, with the help of the enzyme 5-alpha-reductase, enters the form of dihydroteststeron, which, by binding to specific receptors, forms a complex that triggers the rapid division and growth of glandular cells. . The result is prostate hyperplasia. The size of the organ increases and causes obstructive symptoms.

Medications for prostate adenoma based on 5-alpha reductase inhibitors neutralize the action of enzymes, thereby stopping the growth of the tumor, reducing its size and restoring free urination.

In the practice of treating disease with 5-alpha-reductase inhibitors, drugs based on finasteride and dutasteride, a steroid hormone, are used. The advantage of these substances is considered to be a selective effect only on the metabolite dihydrotestosterone. Unlike other hormonal agents, they do not bind to sex hormone receptors, and, thus, do not cause hormone -dependent side effects (obvious sexual dysfunction, male breast growth, softening of bone tissue, muscle atrophy).

Reasons to choose a 5-alpha reductase inhibitor:

  • moderate and severe symptoms of the disease;
  • predominance of severe obstructive symptoms;
  • the volume of the enlarged organ is more than 55 cm³;

Weakness:

  • decreased libido, weak erections;
  • decreased blood levels of prostate -specific antigens, which block the early detection of prostate cancer;

Relief from obstruction symptoms occurs after a few weeks, on average after 4-6 months. At 3-4 years of use, the number of hyperplastic organs is reduced by 25%. The larger the tumor at the beginning of therapy, the faster it will shrink.

Release form: tablet.

Phytotherapy

celandine for the treatment of prostatitis

The effectiveness of the plant in the treatment of disease is due to phytosterols, the main advantage of which is recognized as a combined mechanism of action and minimal side effects.

Reasons for treatment of prostate adenoma with herbal remedies:

  • mild symptoms of the disease;
  • slight increase in tumor size;
  • the patient’s desire to maintain full sexual activity during treatment.

Creeping palm extract (Serenoa repens)

The largest number of randomized clinical trials have been conducted with respect to this plant, as a result of which reliable data on its effectiveness have been obtained.

Herbal medicine for prostate adenoma contains lipidosterol. Their mechanism of action is to inhibit testosterone metabolism by suppressing 5-alpha reductase activity and inhibiting the binding of dihydrotestosterone to the receptor. Due to the anti-inflammatory effect, edema is reduced, the vascular wall is restored and blood flow becomes normal.

The multifaceted effect on the pathological process ensures the elimination of both irritating and obstructive symptoms. An important advantage of using creeping palm extract is the absence of hormone -dependent side effects, which allows you to use this drug without restrictions if you want to live a full sex life. With prolonged use, the number of tumors decreases. Creeping palm extract does not affect the level of prostate -specific antigens in the blood.

The drug for prostate adenoma based on the plant Serenoa repens is considered to be the No. 1 drug. 1 in herbal medicine for this disease. With mild symptoms and small tumor size, monotherapy is performed with drugs based on creeping palms.

Release form: tablets and capsules.

Other herbal remedies

Among the medicinal plants that have a positive effect on this disease, there are also:

  • African plum bark extract (Pygeum africanum). The active ingredient is lipidosterol, which has clear anti-inflammatory properties, inhibits uncontrolled cell growth, reduces the hyperexcitability of the muscular layer of the bladder and urethra, thereby eliminating irritating symptoms, and also slightly reduces the amount of education.
  • Hypoxis rooperi plant extract is a combination of phytosterols and glycosides. The substance inhibits the inflammatory process, normalizes the tone of the ducts of the genitourinary organs, and eliminates the phenomenon of disurik. The substance normalizes fat metabolism in the body.
  • pumpkin seed oil (Cucurbita pepo) has anti-inflammatory, anti-proliferative, metabolic properties, and also stimulates the immune system, facilitates urination, reduces pain.
  • nettle root (Urtica dioica). Reduces the inflammatory process, the phenomenon is traced, does not affect the size of the tumor;
  • extracts of some tropical plants.

Combination treatment - a modern approach

The main position in the treatment of hyperplasia is occupied by 3 groups of drugs:

  1. Alpha blocker.
  2. 5-alpha reductase inhibitors.
  3. Phytoperset.

Combined options:

  • with severe disease symptoms and a significant increase in tumors, it is advisable to use a combination of alpha blockers and 5-alpha-reductase inhibitors. Alpha blockers begin to function after a few hours or days, and the clinical effects of 5-alpha-reductase inhibitors appear after a few months. The negative side of combination therapy is the full range of side effects noticed from both drug groups. The drug for prostate adenoma based on tadalafil is a ready -made combination drug. It also has a therapeutic effect in erectile dysfunction, therefore, it is prescribed for the treatment of hyperplasia only for sexually active men with a healthy heart and blood vessels. Available in tablets;
  • irritating symptoms and tendency to tumor development: alpha-adrenoblocker + phytopreparation;
  • obstructive symptoms and large tumor size: 5-alpha reductase inhibitor + phytopreparation.

Medicines from animals

In the process of treatment, drugs-extracts of dried animal organs have successfully proven themselves. Remedies for prostate adenoma based on extracts of the prostate gland of young bulls who have reached puberty have a complex effect: anti-inflammatory, decongestant, analgesic, normalizes blood flow.

With infectious complications, the means used for the treatment of prostatitis are used.

Remedy for prostatitis

Drug treatment of prostatitis is complex. Major funds:

  1. Antibiotics:
    • fluoroquinolones;
    • macrolide;
    • tetracycline.

    These substances are able to penetrate into the tissues of the affected organs and destroy bacteria - the cause of prostatitis. They are used in the form of tablets and injections.

  2. proteolytic enzymes. Enzymes interfere with the process of organ fibrosis.
  3. Venotonic. To normalize venous circulation.
  4. Anti-inflammatory drugs:
    • hormone injections;
    • non -steroidal drugs.
    • Drugs from animals (same as treatment of hyperplasia).
    • Phytopreparations (similar to the treatment of hyperplasia).

For the treatment of prostate adenoma and prostatitis, Chinese patches have now become popular - a concentrate of 7 medicinal herbs, however, clinical studies in this area have not been conducted.